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KMID : 0988920140120010066
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Intestinal Research
2014 Volume.12 No. 1 p.66 ~ p.69
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Refractory Duodenal Crohn’s Disease Successfully Treated with Infliximab
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Kim You-Lim
Park Young-Sook
Park Eun-Kyoung
Park Dae-Rim
Choi Gyu-Sik
Ahn Sang-Bong
Kim Seong-Hwan
Jo Yun-Ju
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Abstract
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Crohn’s disease (CD) may involve any part of the gastrointestinal tract, from the mouth to the anus. Approximately >90% of cases occur in the small bowel and colon. Upper gastrointestinal involvement, especially duodenal manifestation, is relatively rare. Therefore, adequate medical treatment for duodenal CD has not yet been established. We report a case of CD with duodenalinvolvement. A 46-year-old man with Crohn’s ileocolitis presented to our hospital with right upper quadrant pain. An endoscopyshowed a deep excavated ulcer with deformity at the duodenal bulb, and he was initially treated with azathioprine (1 mg/kg), Pentasa (3.0 g/day), and a proton pump inhibitor for 1 year. However, the deep ulcer did not heal. Therefore, infliximab infusion therapy was initiated, and the duodenal lesion completely resolved on follow-up esophagogastroduodenoscopy. We report a case of duodenal CD that completely resolved following infliximab infusion, with a review of the literature. (Intest Res 2014;12:66-69)
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KEYWORD
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Crohn’s disease, Duodenum, Infliximab
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